Ys Life Science Co. Ltd.

Yonsung Fine Chemical Co., Ltd.

Areum Baek

Hyunik Shin

Kee Young Lee

Chang Young Oh

Hyun Ik Shin

Seunghui Sin

Seongtaek Kim

Youngsik Chung

Eunim Jeong

Yongseo Park

Provided is a novel crystalline form of lifitegrast and a pharmaceutical composition containing the novel crystalline form of lifitegrast. The crystalline form of lifitegrast has improved solubility and excellent stability against heat and moisture, thereby being effectively used for preparing a pharmaceutical composition.

Crystalline form of lifitegrast, and pharmaceutical composition comprising the same

An eribulin salt formed by combining an eribulin free base with a low molecular weight amine compound through a diacid compound is disclosed. As the diacid compound, edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid, pyrophosphoric acid, and combination thereof may be employed. As the amine, ammonia, cyclohexylamine, dicyclohexylamine, and a combination thereof may be employed. The eribulin salt can be crystallized by recrystallization to produce a crystalline eribulin salt with increased purity.

Crystalline salt of eribulin

An eye drop composition for treating glaucoma is disclosed. The eye drop composition includes a prostaglandin analogue, a thickening agent, and a solubilizing agent, wherein the thickening agent is carboxymethylcellulose or a salt thereof, and the solubilizing agent is tyloxapol.

Ophthalmic composition for glaucoma treatment

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Suwon-si, South Korea

Areum Baek