Pacific Biosciences of California, Inc.

Arekadiusz Bibillo

John Lyle

Fred C Christians

Paul S Peluso

Thang Pham

Geoff Otto

David R Rank

Insil Park

David Kagen Hanzel

Sonya Clark

Paul Mitsis

Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.

Polymerases for nucleotide analogue incorporation

Compositions that include polymerases with features for improving entry of nucleotide analogs into active site regions and for coordinating with the nucleotide analogs in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.

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Cupertino, CA, United States of America

Arekadiusz Bibillo