Other

Armour Pharmaceutical Company

Usv Pharmaceutical Corporation

Armour Pharmaceutical

Lavender, Ardis R.

Ardis R Lavender

George Vrany

Emidio Di Martino

Michael Diker

A system, method and device for continuous mass transfer in fluids, such as blond. A mass transfer device is connected in a closed path between a blood source and a reservoir. Pumps and valves are provided to move the blood through the mass transfer device sequentially in a first path from the blood source to the reservoir and in a second pass from the reservoir to the blood source. Material may be added to the blood flowing from the source. The mass transfer device may be a fractionating device, In that case the system and method may be used for plasma collection, or for displacement of water preparatory to freezing of the blood, or for the formation of washed blood cells from either whole blood or thawed blood. The system and method may be used for hemodialysis, in which case the mass transfer device is a dialyzer. The fractionating device includes interleaved blood plates and blood fraction collection plates separated by semipermeable membranes. The device is arranged with two separate passages therethrough, each comprising a pair of parallel blood flow channels; the passages being connected in series by external tubing.

System and method for mass transfer between fluids

A system, method and device for continuously fractionating blood in situ. The fractionating device is connected in a closed loop to the donor and includes interleaved blood plates and blood fraction plates separated by a semipermeable membrane. Grooves in the plates direct blood flow and blood fraction collection. Uniform distribution among the plates and intraplate is obtained by manifolds.

System, apparatus and method for continuously fractionating blood in situ

A system, method and device for continuously fractionating blood in situ. The fractionating device is connected in a closed loop to the donor and includes interleaved blood plates and blood fraction plates separated by a semipermeable membrane. Grooves in the plates direct blood flow and blood fraction collection. Uniform distribution among the plates and intraplate is obtained by manifolds. The input and output pressures of the blood pump are sensed and inputed to an microprocessor, into which donor data including weight, sex, and hematocrit is also keyed by the user. The microprocessor operates under program control to calculate, based on the donor data, the amount of plasma to be collected and the amount of anticoagulant to be added. The program controls the operation of the extracorporeal devices, regulates the operating parameters, and stops the procedure when the predetermined amount of plasma has been obtained.

System and method for continuously fractionating blood in situ

Combined plasmapheresis console and fluid exchanger

A bag clamping arrangement, such as an arrangement for automatically controlling the filling volume and overflow of a liquid conducted into a flexible bag which is clamped in the arrangement. The bag clamping arrangement is essentially constituted of a rigid upwardly open receptacle of substantially rectangular or a relatively large upper compartment, and wherein a narrow compartment which in open communication with the upper compartment depends downwardly from the bottom of the upper compartment so as to extend longitudinally and generally centrally across the full width of the receptacle. The lower compartment includes opposite parallel sidewalls which are down so as to form a reducing compartment width therebetween. Towards the lower end of the compartment is a plate-like clamping arrangement essentially constituted of a flat plate member which may be manually engaged through an elongate slot and gripping portion proximate its upper horizontal edge. The plate member is provided along its lower edge on both sides thereof with sideways projecting resilient clamping components which, upon being inserted into the lower compartment of the receptacle, are biased towards the plate member and are dimensioned to clampingly engage between the sides of the clamping plate and the contiguous sidewalls of the lower compartment. A flexible bag is positioned on either one side, or two bags each respectively on the opposite sides of the clamping plate member prior to insertion of the latter into the receptacle, with the lower end portion of the bag or bags extending between the respective resilient clamping component and the facing surface of the clamping plate member such that, upon introduction of the clamping plate member downwardly into the lower compartment, the applicable resilient clamping component upon being biased towards the plate member, will clamp the lower bag portion against the facing surface of the clamping plate member, thereby ensuring the secure clamping of the bag.

Bag clamping arrangement

The Specification discloses an improved peristaltic Roller Pump for pumping fluids through a flexible tubing. First and second surge release radii are formed on a semicylindrical reaction wall to minimize back surge or fluctuations in pump line pressure as the pump rollers engage and disengage the reaction wall. Improved sloped or angles sweep vanes are provided in front of each roller for collecting the tubing and directing it through a discharge throat into the path of the oncoming roller thereby minimize jamming, kinking or other entanglement of small diameter tubing when used in a roller pump. A novel and inexpensive construction arrangement provides for quick simple and precise adjustment of both rollers simultaneously to enable the operator to quickly adjust the pump, or to disassemble the pump for cleaning or sterilization. The pump utilizes a pair of reciprocating pump arms which are actuated by a single cam means to provide for a simultaneous and identical adjustment of each of the rollers with respect to the pump wall.

Peristaltic roller pump

The Specification discloses a parallel-piped freezing frame having a plurality of compartments for freezing of flexible bags of plasma or other biological fluid. A slidable freezing plate is mounted within each compartment and cam means are provided for directing the freezing plate downwardly and laterally against a side wall of the component. The freezing plate and associated planar wall thereby mold the flexible bag into a flat but slightly wedge-shaped configuration. A freezing medium such as alcohol circulates through the freezing frame to freeze the contents of the flexible bag.

Freezing frame for a plasma container

An apparatus, system and process for continuously fractionating blood in which blood from a donor is passed along a semipermeable membrane through which passes a fraction to be collected. Turbulent blood flow is maintained to prevent a filter cake from building up on the membrane surface and thereby prevent the blood fraction from passing therethrough. The system includes the blood fractionator, a collection apparatus, a blood pump and appropriate blood clot filters. The rapid blood fraction production rate and the small size of the device facilitates in situ collection of the blood fraction. Fractionation rates upwards of 30 volume percent of blood flow are possible.

Device and method for continuously fractionating blood to produce plasma

A mass transfer device consists of a stack of alternating plates and membranes in which each plate includes on each surface two manifolds for distributing and collecting fluid transversely of the plate. Headers interconnect the stack with the plate manifold fluid inlets and outlets to distribute and collect fluid uniformly to and from each plate. Inlet and outlet manifold channels of each plate surface are connected by channels formed in the central portion of the plate. Mass transfer occurs across the membrane supported between adjacent plates with a first fluid on one side and a second fluid on the other side. Substantially uniform inter- and intra- plate fluid distribution and thin fluid films enhance mass transfer. The device, with slight alterations appropriate to the application, is useful for dialysis, hemodialysis, blood oxygenation, reverse osmosis, heat exchange, or gas scrubbing.

Mass transfer device

A device for distributing fluid from an inlet to an outlet, in which a series of plates in stack configuration provides a continuously subdividing fluid flow path between the inlet and the outlet such that the fluid distribution at the outlet is over a substantially greater area than the fluid at the inlet. Each plate in the stack of plates is provided with a plurality of apertures which in stack configuration define a plurality of fluid flow paths symmetrically about the axis of the fluid inlet.

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Chappaqua, NY, United States of America

Ardis R Lavender