Massachusetts Institute of Technology

Dana-Farber-Cancer Institute Inc.

The Broad Institute, Inc.

Aravind Subramanian

Todd R Golub

Justin Lamb

David D Peck

The present invention provides compositions and methods for making and using a transcriptome-wide gene-expression profiling platform that measures the expression levels of only a select subset of the total number of transcripts. Because gene expression is believed to be highly correlated, direct measurement of a small number (for example, 1,000) of appropriately-selected transcripts allows the expression levels of the remainder to be inferred. The present invention, therefore, has the potential to reduce the cost and increase the throughput of full-transcriptome gene-expression profiling relative to the well-known conventional approaches that require all transcripts to be measured.

Growing community of inventors

Cambridge, MA, United States of America

Aravind Subramanian