Kissei Pharmaceutical Co., Ltd.

Arao Ujiie

Tetsuhide Kamijo

Hiromu Harada

Atsushi Tsubaki

Naoyuki Tsutsumi

Masahiko Uchida

Akira Iyobe

Toshiaki Yamaguchi

Koji Kamata

Juichi Fukuyama

Keiji Miyazawa

Hideo Nagata

Shuichiro Hamano

A method for treating patients to inhibit restenosis associated with coronary intervention, which comprises administering compounds of the class of aminobenzoic acids, specifically 2-(3,4-dimethoxy-cinnamoyl)-aminobenzoic acid or its pharmaceutically acceptable salt at a dosage which is sufficient to maintain the plasma concentration at about 100.mu. molar for a period of time of less than three months.

Method for the treatment or prevention of restenosis associated with

Piperidino-3,4-dihydrocarbostyril compounds represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy group or an acyloxy group having 2 to 11 carbon atoms; one of R.sup.2 and R.sup.3 represents a nitro group, a cyano group, an alkoxycarbonyl group having 2 to 7 carbon atoms, an alkyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 3 carbons atoms, or a halogen atom, and the other represents a hydrogen atom; and pharmaceutically acceptable salts thereof, exhibit platelet aggregation inhibiting activity and thus being useful as therapeutic agents for the prevention or treatment of cerebral ischemic disorders and arterial ischemic disorders.

Piperidino-3,4-dihydrocarbostyril compounds

Benzofuro[3,2-c]quinoline compounds of the formula: ##STR1## wherein A represents a group of the formula of --CH.sub.2) .sub.m or --CH.sub.2 CH(OH)CH.sub.2 --; Y represents an N,N-di-alkylamino group, an N-mono-alkylamino group or a nitrogen atom-containing aliphatic geterocyclic group; n represents 0 or 1; m represents an integer of from 1 to 3, and pharmaceutically acceptable acid addition salts thereof, possess a strong inhibitory action on bone resorption, a stimulatory effect on ossification.

3-alkoxy substituted benzofuro[3,2-c]quinolin-6-one compounds

Benzofuro[3,2-c]quinoline compounds of the general formula: ##STR1## wherein (1) each of R.sup.1 and R.sup.2 is the same, and represent a group of the formula of --OR.sup.3 in which R.sup.3 represents a carbamoyl group, an N-mono-alkylcarbamoyl group, an N,N-dialkylcarbamoyl group, an alkylsulfonyl group, a formyl group or an aliphatic acyl group which may have an alkoxycarbonyl group as a substituent; m represents zero, 1 or 2; n represents zero or 1; with the proviso that n is not zero when m is zero,

Acylated benzofuro[3,2-c]quinoline compounds with utility as treatments

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Nagano, Japan

Arao Ujiie