Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar

Aranka Lay Nee Konya

Tibor Mezei

Zoltan Budai

Lujza E Petocz

Katalin Grasser

Ibolya Kosoczky

Eniko Szirt Nee Kiszelly

Attila Kis-Tamas

Zoltan Vig

Ferenc Jurak

Gabor Gigler

Istvan Gacsalyi

Klara Reiter Nee Esses

Maria Szecsey Nee Hegedus

Peter Gorog

Eniko Kiszelly

Eva Furdyga

Laszlo Magdanyi

Zoltan Vigh

Zsuzsanna Orr

Viktor Andriska

Terez Zubovits Nee Kristof

Istvan Gertyan

Agnes Sokorai Nee Janki

The new compounds of the general Formula I ##STR1## (wherein A stands for a C.sub.2-4 straight or branched chain alkylene group;

Substituted styrene derivatives

The invention relates to selected stereoisomers having the E, E or E, Z configuration and within the Formula (I) ##STR1## wherein N is 2-4, A is alkylene or 2 or 3 carbon atoms, R is phenyl or substituted phenyl and R.sup.1 and R.sup.2 are lower alkyl, or, together with the carbon to which attached, form a heterocyclic ring; and pharmaceutically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions comprising the same. The compounds of the general formula (I) can be used in therapy due to their narcosis potentiating, analgesic and antiarrhythmial effect.

2-(phenylmethylene)-1-(diaminoalkoxy) cycloalkanes and their

The invention relates to pharmaceutical compositions possessing valuable antianginal activity. These compositions show higher activity and more favorable therapeutic indices than the reference compound Prenylamine. Preparation of different kinds of pharmaceutical compositions, such as tablets, dragees, capsules and injectable solutions, containing compounds of general formula (I) ##STR1## or their acid addition salts as active ingredients, is disclosed, wherein in formula (I)

Pharmaceutical compositions with antianginal activity

The invention relates to new N-substituted amino propane sulfonic acid derivatives of the Formula I ##STR1## and salts and hydrates thereof, a process for the preparation thereof and plant growth regulating agents comprising the same wherein

N-substituted amino propane sulfonic acid derivatives and plant growth

The invention relates to new bicyclo(2.2.1)heptane derivatives of the general formula I ##STR1## wherein R represents a C.sub.1-12 alkyl group optionally substituted by a lower alkoxy group, a C.sub.2-4 alkenyl group or a phenyl-(lower alkyl) group optionally substituted on the phenyl ring by one or more lower alkoxy groups or halogen atoms. The invention relates further to plant growth regulating compositions comprising as active agent 0.001 to 95% by weight of a racemic and/or optically active compound of the general formula I, wherein R has the above defined meanings, along with a conventional organic or inorganic, solid and/or liquid carrier and/or filler and/or diluent and/or surfactant. The invention encompasses also the preparation of the compounds of the general formula I which comprises reacting a racemic or optically active compound of the general formula II ##STR2## wherein Y is an oxygen or sulfur atom or an oxim group, with a compund of the general formula III

Bicyclo(2.2.1)heptane oximes used for plant growth regulating

The invention relates to novel oxime ethers of the general formula /I/ and acid addition salts and quaternary ammonium derivatives thereof, ##STR1## wherein A represents a C.sub.2-6 straight or branched alkylene chain,

Oxime ethers and pharmaceutical compositions containing the same

The invention relates to novel basic ethers of the general formula /I/ and pharmaceutically acceptable acid addition salts and quaternary salts thereof, ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and represent a C.sub.1-5 alkyl group or a C.sub.3-6 cycloalkyl group or they form, together with the adjacent nitrogen atom, a heterocyclic ring containing 4-7 carbon atoms and optionally a further hetero atom, e.g. an oxygen, sulfur or nitrogen atom, and this latter may be optionally substituted by a C.sub.1-3 alkyl, benzyl or phenyl group,

Basic ethers and pharmaceutical compositions containing the same

Racemic or optionally active 2-(propargyloxyimino)-1,7,7-trimethyl-bicyclo[2,2,1]heptane of the formula (I) ##STR1## or a mixture of these isomers is prepared by reacting a racemic or optically active 1,7,7-trimethyl-bicyclo[2,2,1]heptane derivative of the general formula (II), ##STR2## wherein Y stands for oxygen atom, sulfur atom or oxime group, with a propyne derivative of the general formula (III),

Plant growth regulating compositions

The invention relates to novel cyclododecane derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 represent independently from each other a hydrogen atom, a C.sub.1-6 alkyl group or a C.sub.3-8 cycloalkyl group, or R.sup.1 and R.sup.2 form together with the nitrogen atom to which they are attached a heterocyclic ring containing 4 to 7 carbon atoms and optionally a further heteroatom selected from the group consisting of oxygen, sulphur and nitrogen, said ring may be optionally substituted by a C.sub.1-3 alkyl or benzyl group; and A represents a C.sub.2-6 straight or branched alkylene chain, and optically active isomers, acid addition salts and quaternary ammonium derivatives thereof. The invention relates further to an analogous process for the preparation of said compounds, to pharmaceutical compositions containing said compounds as the active ingredient and to a process for the preparation of said pharmaceutical compositions. The cyclododecane derivatives of the invention possess valuable biological properties.

Cyclododecanone oximes

Racemic or optically active 2-(propargyloxyimino)-1,7,7-trimethyl-bicyclo[2,2,1]heptane of the formula (I) ##STR1## or a mixture of these isomers is prepared by reacting a racemic or optically active 1,7,7-trimethyl-bicyclo[2,2,1]heptane derivative of the general formula (II), ##STR2## wherein Y stands for oxygen atom, sulfur atom or oxime group, with a propyne derivative of the general formula (III),

Plant growth regulating and insecticidal compositions

Oxime ethers of the formula ##STR1## wherein R stands for a phenyl group which may be substituted by a halogen chlorine atom or by one to three methoxy groups;

Oxime ethers

The invention relates to novel oxime ethers of the formula I ##STR1## wherein R stands for a phenyl group which may be substituted by a halogen atom or by one or more C.sub.1 -C.sub.4 alkoxy, hydroxyl, nitro or di(C.sub.1 -C.sub.3 alkyl)amino groups,

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Budapest, Hungary

Aranka Lay Nee Konya