Korea Institute of Radiological & Medical Sciences

Arang Son

Jie Young Song

In Sung Jung

Ji Yeon Ahn

Ky Youb Nam

Seung Yong Seo

Saelooom Lee

Yuan Yue

Hyun Kyung Choi

Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.

Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient

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Seoul, South Korea

Arang Son