University of California

Aparna Baranwal

Jogeshwar Mukherjee

Nehal Mahendra Shah

Kenneth Dang

Gurleen Samra

Megan Rose Felix

Heather Ho

The disclosure provides for multi-targeting agents that assist in the targeted removal of amyloid beta plaques from the brain and surrounding vasculature of subjects with Alzheimer's disease, and methods of treatment thereof.

Multi-targeting agents for Alzheimer's disease therapy

Various compositions and methods for Quasi-Amadori products and derivatives thereof are contemplated in which a halogenated carbohydrate is reacted with a primary amino group of an affinity ligand. In especially preferred aspects, the Quasi-Amadori product is formed from 2-fluorodeoxyglucose and an affinity moiety that preferentially or selectively binds to a neural cell or neural structure. Where contemplated compounds includeF, PET imaging using compounds presented herein is especially preferred.

Compositions and methods for 18F-fluorodeoxyglycosylamines

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Cerritos, CA, United States of America

Aparna Baranwal