International Business Machines Corporation

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Other

Js Innopharm (shanghai) Ltd.

Js Innomed Holdings Ltd.

Ao Qiong Li

Yuanshan Yao

Jian Li

Shuhui Chen

Yuan Chen

Hongwei Li

Bin Chen

Kun Peng Wang

Wen Kang Xu

Yicheng Feng

Jintao Zhang

Chengshuai Yang

You Miao Zhang

Shanzhong Jian

Ran Xu

Shan Shan Zhao

Zhensheng Huang

Dongdong Tian

Bo Wang

Wei Zhang

Min Zhu

Shaojun Wei

Leibo Liu

Wen Bao Yin

Guoqing Cao

Shouyi Yin

Qun Li

Zhaoyin Wang

Bing Yao

Wei Xd Li

The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.

Cyclic molecules as Bruton's tyrosine kinase inhibitor

The present disclosure provides a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds. They are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof

Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleamine 2, 3-dioxygenase 1 (IDO1), potentially useful in the treatment of diseases treatable, such as cancers. 

Heterocyclic compounds, compositions comprising heterocyclic compound, and methods of use thereof

Provided are a tricyclic compound as shown in formula (I) as a CRTH2 inhibitor, or a pharmaceutically acceptable salt, a tautomer, a stereoisomer or a solvate thereof, and the use thereof in treating diseases related to CRTH2 receptors. 

Tricyclic compound as CRTH2 inhibitor

A computer-implemented method includes positioning a sliding window over a string of data and calculating a hash value using a rolling hash function for data encompassed by the sliding window. The method includes determining whether the calculated hash value for the data encompassed by the sliding window matches the value of an element in a cut point candidate (CPC) array by comparing the calculated hash value to the value of a first element in the CPC array. In response to the calculated hash value being equal to the value of the first element in the CPC array, the method includes defining an index of the sliding window as the cutting point for a data block.

Fixed chunk size deduplication with variable-size chunking

A computer-implemented method, according to one embodiment, includes: sending one or more instructions to a web crawler to identify presentation videos on the internet and capture video data therefrom. In response, video data which corresponds to various presentation videos on the internet is received from the web crawler. The video data is used to define influence factors, such that different combinations of the influence factors represent different conditions of a presenter in the presentation videos. The video data is also used to define labels, where different combinations of the labels represent different conditions of one or more audience members in the presentation videos. Furthermore, structured data is generated by correlating certain presenter conditions with certain audience conditions, and the structured data is stored in memory.

Interactive virtual simulation system

The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor. 

Indole derivative used as CRTH2 inhibitor

The present invention discloses an INS network-based anti-fault attack method of random infection, comprising the steps of sending the plain-text into an encryption processor, wherein two groups of cipher text are outputted through temporal or spatial redundancy; conducting XOR operation) on the two groups of said cipher text output to obtain the output difference; sending the said output difference into an infection function module to initiate an infection operation to obtain the infection result; conducting XOR operation on any of said groups of cipher text output to generate the final output. The present invention can realize the randomization of infection function in infection countermeasures, reduce the successful probability of fault attack and improve the safety of the circuit.

One INS network-based anti-fault attack method of random infection

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Shanghai, China

Ao Qiong Li