Arsenal Biosciences, Inc.

Anzhi Yao

Aaron Cooper

Michelle Nguyen

Xinying Zheng

Somya Khare

Brendan Galvin

Katherine Harris

Natalie Bezman

Stephen Santoro

Matthew Drever

John Gagnon

Samuel A Williams

Duy Nguyen

Harbani Kaur Malik Chaudhry

Omar Khan

Levi Gray-Rupp

Jasper Williams

Thomas Gardner

Zhen Jian Zhou

Amy-Jo Casbon

Angela Boroughs

Adam Litterman

Nicole Allen

Provided herein are antibodies and chimeric priming receptors that bind PSMA and antibodies and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.

Systems targeting PSMA and CA9

Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Immune cells having co-expressed shRNAS and logic gate systems

Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Safe harbor loci

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San Francisco, CA, United States of America

Anzhi Yao