King Fahd University of Petroleum and Minerals

King Saud University

King Abdulaziz City for Science and Technology

Anvarhusein Abdulkadir Isab

Muhammad Altaf

Ali Alhoshani

Adam Ahmed Abdullah Sulaiman

Said S Al-Jaroudi

Adam A A Sulaiman

Mohammed Yagoub Jomaa

Adam Ahmed Abdallah Seliman

Abdulaziz Al-Saadi

Muhammad Ali Ehsan

Khalid Omer

Muhammad Monim-Ul-Mehboob

Saleh Abdulaziz Altuwaijri

Mohammed Ismail Wazeer

Mohammad Altaf

Abdul Rajjak Shaikh

Haseeb Ahmad Khan

Abdullah Saleh Alhomida

Ali Al-Hoshani

Ali Osman Altoum

Mohammed Ismail Mohammed Wazeer

A gold(III) complex of formula (I) or formula (II)

Pharmaceutical composition with primary and secondary therapeutic agents

The present disclosure relates generally to anti-cancer pharmaceuticals. More specifically, the disclosure is directed to gold complexes of Formula I with anti-cancer properties. The disclosure also provides a pharmaceutical composition comprising the complexes, a process of synthesizing the complexes and a method of treating cancer. The complexes of the present disclosure have a multi-target approach to cancer therapeutics by inducing cell apoptosis, cytotoxicity, mitochondrial membrane potential depolarization and increasing reactive oxygen species in cancer cells.

Anti-cancer gold complex, process of synthesis and method of treatment thereof

Injectable gold-based pharmaceutical composition

Anti-cancer composition containing gold and cytotoxic agent

A gold (III) complex of formula (I) or formula (II)

Liquid pharmaceutical composition of gold

Cytotoxicity assay composition and gold (III) complex

Solid pharmaceutical gold-based composition

Alkyl-terminated thiocarbamate complex and method for treating cancer

Alkyl amine dithiocarbamate gold complex for cancer treatment

Platinum(II) ammine selenourea complexes and methods of treating cancer

The invention is directed to a method of treatment of proliferative diseases or disorders such as cancer with gold(I) N-heterocyclic carbene (NHC) thiourea or substituted thiourea complexes, to the complexes per se and to therapeutic compositions containing these gold(I) based complexes.

Method of treating cancer and other proliferative diseases with a gold(I) complex

Gold(I) N-heterocyclic carbene thiourea complex and therapeutic compositions thereof

Method of treating a proliferative disorder by administering a thiourea gold(I) complex

A gold(III) complex of formula (I) or formula (II) 

Bipyridine and bipyrimidine gold(III) dithiocarbamate complexes and methods of treating cancer

Mixed ligand phosphinogold(I) complexes as anticancer agents. The gold(I) ion of the complexes is coordinated to a phosphine and a dithiocarbamate or halogen ligand. Also described are a pharmaceutical composition incorporating the phosphinogold(I) complex, a method of synthesizing the phosphinogold(I) complex, and a method of treating cancer. The phosphinogold(I) complexes exhibit potent cytotoxicity against lung, cervical, and liver cancer cells.

Phosphinogold(I) complexes and methods of treating cancer

Growing community of inventors

Dhahran, Saudi Arabia

Anvarhusein Abdulkadir Isab