Codexis, Inc.

Anupam Gohel Prafulchandra

Steven James Collier

Derek J Smith

Jeffrey C Moore

Haibin Chen

Fabien Louis Cabirol

Tao Li

Yong Koy Bong

Yang Hong

Martina Quintanar-Audelo

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Biocatalysts and methods for hydroxylation of chemical compounds

Engineered proline hydroxylase polypeptides and methods

Engineered proline hydroxylase polynucleotides and methods

Methods for hydroxylyation of chemical compounds

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts, methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.

Engineered proline hydroxylase polypeptides

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Auburn Hills, MI, United States of America

Anupam Gohel Prafulchandra