The United States Government As Represented by the Department of Veterans Affairs

The UAB Research Foundation (The University of Alabama at Birmingham)

Southern Research Institute

Southern Reserach Institute

Anupam Agarwal

Mark J Suto

Bini Mathew

Amie M Traylor

Corinne E Augelli-Szafran

Marina Fosso Yatchang

Ritesh Kumar Srivastava

Suhail Muzaffar

Mohammad Athar

Jasim Khan

The present disclosure is concerned with purine diamine compounds for the treatment of conditions associated with BRD4, RIP3K, and/or IL6 signaling dysfunction such as, for example, cancer (e.g., lung cancer, skin cancer, bladder cancer, kidney cancer, liver cancer), arsenicosis, arsenic poisoning, inflammation, skin lesions, dysfunction of systemic organs, and skin blisters. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Development of potential antidotes for arsenicals

The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Compounds for the treatment of acute and chronic kidney disease

The present disclosure is concerned with biaryl aminomaleimide compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Growing community of inventors

Mountain Brook, AL, United States of America

Anupam Agarwal