Cfd Research Corporation

The University of Oklahoma

Anuj Singhal

Robert H Cichewicz

Lin Du

Hanumantha Rao Paritala

Abigail Grace Edwards

JianLan You

A compound can have a structure of Formula A, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof: wherein ring A is a phenyl, indolyl, naphthyl, or benzothiazolyl; X is S, SO, or SO; Y is a linker or bond; Z is CH, CR, or N; Zis C or N to form an imidazopyridine; each Z, Z, or Zis independently CH, CR, or N; each Zor Zis C or CH; each R, R, and Ris independently a substituent, and at least one of R, R, or Ris a substituent other than a hydrogen; m is 0, 1, 2, 3, or 4; and n is 0 or a positive integer. The compounds can have specific substituent patterns.

Antimicrobial compounds, compositions, and articles of manufacture for selectively inhibiting pathogenic microbes

In an aspect, the disclosure pertains to inhibitors of ANGPTL4; synthesis methods for making disclosed compounds; pharmaceutical compositions comprising disclosed compounds; methods of treating disorders of uncontrolled cellular proliferation, e.g., a cancer; and methods of treating a disease associated with an ANGPTL4 dysfunction using disclosed compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Methods and compositions for treatment of cancer

A method of selectively inhibiting pathogenic microbes includes: providing a compound that is functional as a selective antimicrobial having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a pathogenic microbe with the compound such that the pathogenic microbe is selectively inhibited; wherein: ring A is a cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or polycycle combination thereof; X is S, SO, or SO; Y is a linker or bond; Z is CH, CR, or N; Zis C or N to form an imidazopyridine; each Z, Z, or Zis independently CH, CR, or N; each Zor Zis C or CH; each R, R, Rand/or Ris independently a substituent; m is 0, 1, 2, 3, or 4; and n is zero or a positive integer.

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Huntsville, AL, United States of America

Anuj Singhal