The Brigham and Women's Hospital, Inc.

Massachusetts Institute of Technology

Vayu Global Health Innovations, LLC

Anuj Bellare

Thomas S Thornhill

Robert E Cohen

Richard D Scott

Wolfgang Fitz

Prem V Pavoor

Brian P Gearing

Andreas H Gomoll

Kamyar Mollazadeh Moghaddam

Thomas Friedrich Burke

An apparatus having an adjustable ambient air-oxygen blender that adjustably mixes ambient air with an oxygen supply, especially where a size, diameter or flow rate of an orifice is mechanically adjustable so as to control a quantitative mixing function of the blender.

Adjustable ambient air-oxygen blender

One aspect of the present invention relates to an implantable medical device comprising a surface coated with a polyelectrolyte multilayer, wherein said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of preparing a PEM-coated implantable medical device, comprising the step of applying a film to a surface of an implantable medical device, wherein said film comprises a polyelectrolyte multilayer and said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of reducing the wear between two contacting materials, comprising the step of moving a first material in contact with a second material in an environment, wherein a first surface of said first material is in contact with a second surface of said second material, wherein said first surface, said second surface, or both is coated with a polyelectrolyte multilayer, thereby decreasing the wear of said first material, said second material, or both compared to the wear in the absence of said polyelectrolyte multilayer.

Tribological applications of polyelectrolyte multilayers

Highly crystalline, oxidation resistant crosslinked polymeric materials such as crosslinked ultrahigh molecular weight polyethylenes having high wear resistance, enhanced stiffness, enhanced tensile strength, a high level of fatigue and crack propagation resistance, and enhanced creep resistance can be manufactured by the new methods described herein.

Crosslinked polymers

Nanocomposite surgical materials, such as cements, having very fine heterogenous structure are formed by incorporating into a polymeric matrix a well dispersed solid filler having an average mass diameter ranging from about 750 nanometers to about 1 nanometer. The average ligament thickness of the surgical composite cements ranges from about 750 nanometers to about 1 nanometer. Methods and apparatus for avoiding air contact during the preparation and transfer of a cement to an in vivo site are described.

Nanocomposite surgical materials and method of producing them

Nanocomposite surgical materials, such as cements, having very fine heterogenous structure are formed by incorporating into a polymeric matrix a well dispersed solid, liquid or gaseous filler having an average mass diameter ranging from about 750 nanometers to about 1 nanometer. The average ligament thickness of the surgical composite cements ranges from about 750 nanometers to about 1 nanometer. Methods and apparatus for avoiding air contact during the preparation and transfer of a cement to an in vivo site are described.

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Brighton, MA, United States of America

Anuj Bellare