Brown University

Rhode Island Hospital

Rhode Island Board of Education, State of Rhode Island and Providence Plantations

Rhode Island Boad of Education, State of Rhode Island and Providence Plantations

Anubhav Tripathi

Jeffrey R Morgan

Jinkee Lee

William Robert Patterson

Arijit Bose

Anita Shukla

Leonard A Mermel

Christina Bailey-Hytholt

Arjit Bose

Toni-Marie Achilli

Stephanie McCalla

Jennifer Fieber

Leah Seward

Aleksey Novikov

Aartik Sarma

John Murphy

Andrew Blakely

Carmichael Ong

The invention provides a lipid bilayer mimicking the lipid composition of the placenta. The lipid composition provides an in vitro placenta model using the lipid composition of the placental cell membrane.

Placental lipid bilayer for cell-free molecular interaction studies

A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement of the gripper, assembles aggregations of cells on a separate membrane within the vessel, thereby creating a three-dimensional assembly of aggregations of cells that fuse and can be employed in surgical procedures as a unitary tissue of adherent cells. The aggregations of cells, as assembled, can assume three-dimensional configurations distinct from any one of the component aggregations of cells assembled.

Device and method for engineering living tissues

Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the spheroids. Uptake of a substrate of the efflux pump and distribution of a substrate for the efflux pump within the spheroids is imaged to thereby select drugs that inhibit the efflux pump or do not block gap junction communication. Selected drugs can then be employed to treat a tumor.

Differential effects of drugs on transport in a multi-layer 3D spheroid model

A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a blotting step. A sample liquid droplet is formed at the end of a capillary, wherein a portion of the liquid is transferred to the TEM sample grid by contact. The excess volume in the liquid droplet is then retracted by an adjacent capillary. After a predetermined time interval, the retraction capillary is moved toward the drop of the sample to remove the excess volume. As compared to a conventional machine, where the blotting procedure can deform the structure of the molecule of interest, the present invention utilizes a very low shear rate for removal of the excess sample fluid.

Microfluidic blotless cryo TEM device and method

Method and system for automating sample preparation for microfluidic cryo TEM

This invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of thetcdB, tcdC, or cdtB genes, wherein, wherein said primer consists of a sequence selected from the group consisting of SEQ ID NOS: 1 through 9, or a sequence that exhibits no more than one substitution of a base to a sequence selected from the group consisting of SEQ ID NOS: 1 through 9 and method for polymerase chain reaction (PCR) determining of the presence of a toxigenic strain ofin a biological sample utilizing said probes.

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Growing community of inventors

Northboro, MA, United States of America

Anubhav Tripathi