Advaxis, Inc.

University of Pennsylvania

University of Georgia Research Foundation, Inc.

Anu Wallecha

Yvonne Paterson

Paulo Cesar Maciag

Vafa Shahabi

Reshma Singh

John Rothman

Matthew Seavey

Donald A Harn, Jr

Melissa Gosse

David Fela

Mike Grace

Nicola Mason

Robert Petit

Paulo MaCiag

Poonam Molli

Methods and compositions are provided for lyophilization of bacteria orstrains, such as. Provided are methods for producing a lyophilized composition comprising a bacteria orstrain, formulations for lyophilization comprising a bacteria orstrain, lyophilized bacteria orstrains, and methods of preparing frozen bacteria orstrains for lyophilization.

Compositions and methods for lyophilization of bacteria or listeria strains

The present invention provides methods of treating, protecting against and inducing an immune response against a tumor or cancer, comprising the step of administering to a subject a recombinantstrain. In one embodiment the present invention relates to a recombinantstrain, said recombinantstrain comprising a recombinant nucleic add, said nucleic add comprising a first open reading frame encoding a recombinant polypeptide comprising a first N-terminal fragment of an LLO protein fused to a heterologous antigen or fragment thereof, and wherein said recombinant nucleic add further comprises a second open reading frame encoding a mutant PrfA protein.

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This invention provides methods and compositions for usingas an adjuvant for enhancing immune responses in a subject.

Listeria-based adjuvants

This invention provides methods and compositions for using a live attenuatedfor inhibiting cell-mediated suppression of anti-disease infiltrating T lymphocytes in a subject having the disease.

Provided herein are recombinantstrains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into thegenome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.

Dual delivery system for heterologous antigens

This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant and several sub-dominant epitopes of the antigen.

Compositions and methods for prevention of escape mutation in the treatment of HER2/NEU over-expressing tumors

This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.

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Yardley, PA, United States of America

Anu Wallecha