Orion Corporation

Anu Moilanen

Gerd Wohlfahrt

Olli Törmäkangas

Arja Karjalainen

Harri Salo

Jari Ratilainen

Anniina Vesalainen

Terhi Heikkinen

Paavo Huhtala

Rathna Durga Ramasubramanian

Pranab Kumar Patra

Arputharaj Ebenezer Martin

Pekka Kallio

Compounds of formula (I) or (II) wherein R, R, R, R, R, R', R, R&#x2032;, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

Androgen receptor modulating carboxamides

Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g., in the treatment or prevention of male hypogonadism and age-related conditions such as andropause.

Propionamide derivatives useful as androgen receptor modulators

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Turku, Finland

Anu Moilanen