Bayer Oy

Antti Keinänen

Hannu Nikander

Jukka Koskinen

Christine Talling

Jyrki Pihlaja

Manja Ahola

Pentti Järvelä

Svante Holmberg

Risto Hakala

Piia Hara

Henriikka Korolainen

The present invention relates to a method for modifying release of a therapeutically active agent from an elastomeric matrix, comprising providing a core comprising an elastomeric matrix and a therapeutically active agent; dipping the core to a coating solution of an elastomer, wherein the elastomer comprises 20-35 wt-% of a filler, calculated from the total amount of filler and elastomer; curing the dipped core to provide a coated core. In this method the dipping is provided as a continuous process by pulling the core through the coating solution, using a pulling speed suitable for providing a coating thickness of &#x3b4;-IOOthe filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).

Method for modifying release of a therapeutically active agent from an elastomeric matrix

The membrane shell of an implantable dosage system according to the invention is particularly suitable for subcutaneous applications to release an active agent with steady amounts during a longer period of time. The membrane shell () according to the invention comprises a first half () and a second half (), which both halves comprise a continuous closure edge (), and are adapted to be connected to each other through a closable joint. The closure edges () of the halves comprise at least one groove () and/or at least one protrusion () as continuous or discontinuous, and the membrane shell () is adapted to be closed so that at least one protrusion () and/or at least one groove () of the second half becomes opposed to at least one groove () and/or at least one protrusion () of the first half through a snap-fit joint.

Membrane shell of an implantable dosage system

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Turku, Finland

Antti Keinänen