New England Biolabs, Inc.

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Clotilde K Carlow

The present invention relates to the use of nematode 'cyclophilin-like proteins (CLP)', in a method for identifying compounds capable of binding to and/or inhibiting the peptidyl-prolylcistransisomerase activity of these proteins. Such compounds may be further screened for their ability to inhibit nematode parasites which are not susceptible to the anti-parasitic effects of CsA.

Isolation and production of a cyclophilin-like protein endogenous to

The present invention relates to the use of these cyclophilins, hereinafter referred to as 'cyclophilin-like proteins (CLP)' in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.

Method for identifying anti-nematode compounds

The present invention relates to the use of these cyclophilins, hereinafter referred to as 'cyclophilin-like proteins (CLP)', in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.

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Beverly, MA, United States of America

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