Glaxosmithkline LLC

Smithkline Beecham Corporation

Ligand Pharmaceuticals, Inc.

Glaxo Group Limited

Antony N Shaw

Kevin J Duffy

Kenneth Wiggall

Juan I Luengo

Duke M Fitch

William Henry Miller

Jian Jin

Julian Jenkins

Alan T Price

Ronggang Liu

Andrea K Myers

Michael N Zimmerman

Connie L Erickson-Miller

Stephen F Miller

Sophie Visonneau

Daniel F Eppley

Nannan Liu

Michael N Zimmermann

The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Prolyl hydroxylase inhibitors

The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

N-substituted glycine derivatives: hydroxylase inhibitors

Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Thrombopoietin mimetics

Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.

Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Compounds of formula (I), particularly a compound of formula (Ia), are non-peptide TPO mimetics, useful in the treatment of thrombocytopenia.

Semicarbazone derivatives and their use as thrombopoietin mimetics

Growing community of inventors

Collegeville, PA, United States of America

Antony N Shaw