Merck Sharp + Dohme Corp.

Merck + Co., Inc.

Antony John Davies

Karel Marie Joseph Brands

Jeremy Peter Scott

David R Lieberman

Cameron Cowden

Leslie Joseph Street

Jose Luis Castro Pineiro

William Robert Carling

Andrew Madin

Martin Richard Teall

Ulf H Dolling

Duncan Edward Shaw

Paul Joseph Oakley

Ian Frank Cottrell

Stephen Philip Keen

Brian Christopher Bishop

Gavin William Stewart

James Francis McCabe

Gareth Edward Pearce

Sarah Elizabeth Brewer

Deborah Camille Hammond

There is provided stereoselective route to a compound of formula I: wherein R represents H or an alkali metal, Arrepresents 4-chlorophenyl and Arrepresents 2,5-difluorophenyl.

Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid

The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds. The compounds of formula (A) are useful as &#x3b1;&#x3bd;&#x3b2;3 receptor antagonists 

&#x3b1; v integrin receptor antagonists

A novel process for preparing cyclohexanone derivatives of formula (I) is described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

Synthesis of cyclohexanone derivatives

7-(1,1 -Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo&lsqb;4,3-b&rsqb;pyridazine, and pharmaceutically acceptable salts thereof are selective ligands for GABA receptors useful in the treatment of disorders of the central nervous system.

Substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom

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Princeton, NJ, United States of America

Antony John Davies