West Pharmacuetical Services Drug Delivery & Clinical

West Pharmaceutical Services Drug Delivery and Clinical Research Limited

Antony James Caston

Lisbeth Illum

Paul Williams

Adhesive drug delivery composition

Adhesive material from the fimbriae (esp. Type 1) of bacteria or synthetic analogues or fragments thereof is combined with a drug to provide for attachment to the gut of a mammal, thereby prolonging the transit time of the drug through the gut. The 28 kDa polypeptide from Type 1 fimbriae is the preferred adhesive material (&ldquo;adhesin&rdquo;). The drug is presented in a carrier such as albumin, a polylactide/glycolide copolymer or alginate microcapsules. The adhesin may be incorporated in the carrier during preparation thereof, adsorbed onto the carrier after preparation, or covalently linked thereto, for example with carbodiimide.

Growing community of inventors

Nottingham, United Kingdom

Antony James Caston