Jsc Grindeks

Latvian Institute of Organic Synthesis

Tetra, Sia

Grindeks, a Joint Stock Company

Antons Lebedevs

Ivars Kalvins

Maksims Vorona

Maija Dambrova

Ivars Kalvinsh

Aleksandrs Chernobrovijs

Liga Zvejniece

Grigory Veinberg

Grigorijs Veinbergs

Aleksandrs Cernobrovijs

Anatolijs Birmans

Maris Veveris

Anatolijs Misnovs

Agnija Ievina

Jurijs Ponomarjovs

Larisa Varaceva

Dmitrijs Cernaks

Pugovics Osvalds

Novel betaine salts of acetylsalicylic acid, namely 4-trimethylammoniobutanoate acetylsalicylic acid addition salt (gamma-butyrobetaine acetylsalicylate), L-carnitine acetylsalicylic acid addition salt and 3-(trimethylammonioamino)propanoate (meldonium) acetylsalicylic acid addition salt. Use of meldonium acetylsalicylate as antiplatelet agent for treating various pathologies induced by platelet aggregation, anti-inflammatory and antihyperlipidemic agent.

Acetylsalicylic acid salts

The present invention provides a method for regeneration of chiral 2,2'-cyclopropylidene-bis(oxazolines), such as (3&R,3&#x2032;aR,8aS,8&#x2032;aS)-2,2&#x2032;-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[1,2-d]-oxazole and (45,4&#x2032;5,5R,5&#x2032;R)-2,2&#x2032;-cyclopropylidenebis-4,5-diphenyldihydro-4,5-oxazole, used as a part of complex catalysts for e.g. stereoselective addition reactions, from the reaction mixtures, by selective sorption of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) on a sorbent, such as silica gel, isolation of the sorbent from reaction mixture, desorption of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) from the sorbent with suitable organic solvent and final recovery of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) from the organic solvent used for desorption process. Catalytic quality of recovered compounds does not differ from those in freshly prepared catalysts.

Regeneration of 2,2'-cyclopropylidene-bis (oxazolines)

The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.

[object Object]

Growing community of inventors

Riga, Latvia

Antons Lebedevs