Cytokinetics, Inc.

Amgen Inc.

Antonio Romero

Bradley Paul Morgan

Chihyuan Chuang

Scott E Collibee

Xiangping Qian

Gustave Bergnes

Alex R Muci

Jeffrey Warrington

Zhe Yang

Luke W Ashcraft

Pu-Ping Lu

Mikkel V Debenedetto

David Joseph St Jean, Jr

Joshua Payette

Jeff Gardina

Justin Malinowski

Michael G Johnson

Felix Gonzalez Lopez De Turiso

Alan C Cheng

Russell Graceffa

Alessandro Boezio

Richard Vargas

David C Moebius

John R Butler

Hanmo Zhang

Aroop Chandra

John Yeoman

Vincent DiMassa

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Bisamide sarcomere activating compounds and uses thereof

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, X and mare as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Amino-pyrimidine skeletal muscle modulators

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. 

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Bisamide sarcomere activating compounds and uses therof

Substituted pyridazines as skeletal muscle modulators

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, X, Z, Z, Z, Zand m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use

Amino-pyridazine skeletal muscle modulators

Certain amino-pyrimidines, compositions thereof, and methods for their use

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San Mateo, CA, United States of America

Antonio Romero