Farmitalia Carlo Erba S.p.a.

Farmitalia Carlo Erba S.r.l.

Nerviano Medical Sciences S.r.l.

Pfizer Italia S.r.l.

Antonio Pillan

Paolo Cozzi

Pier P Lovisolo

Ermes Vanotti

Patricia Salvati

Maria Menichincheri

Marina Caldarelli

Alessandra Scolaro

Barbara Forte

Antonella Ermoli

Germano Carganico

Alessandra Cirla

Leone Bertone

Corrado Ferti

Angelo D Volpi

Maurizio Pulici

Umberto Branzoli

Mario Varasi

Paolo Orsini

Nicola Mongelli

Roberto D'Alessio

Marcellino Tibolla

Alessia Montagnoli

Corrado Santocanale

Maria Bergamaschi

The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R, R, R, Rand Rare as defined in the specification. Further objects of the invention are processes and intermediates for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. 

Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors

Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors

Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furane-derivatives as kinase inhibitors

Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

Pyrimidylpyrrole derivatives active as kinase inhibitors

The invention provides N-imidazolyl derivatives of substituted indole of general formula (I) ##STR1## wherein p is an integer of 1 to 4;

N-imidazolyl derivatives of substituted indole

The invention provides new N-imidazolyl derivatives of substituted tetrahydrocarbazoles and cyclopent[b]indoles of general formula (I) ##STR1## wherein n is 1 or 2;

N-imidazolyl derivatives of substituted tetrahydrocarbazole and

N-imidazolyl- and N-imidazolylmethyl-derivatives of substituted bicyclic

A pharmaceutical compositon having activity against nephropathies comprising, as an active agent, a therapeutically effective amount of a compound of formula (I) ##STR1## wherein (a) ##STR2## wherein Y completes a single bond or is oxygen or a --CH.sub.2 -- group and the symbol ##STR3## represents a single bond or (b) ##STR4## ##STR5## and the symbol ##STR6## represents a double bond; one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is --CH.sub.2 OH, C.sub.2 -C.sub.4 acyl, ##STR7## in which each of R.sub.1, R.sub.8 and R.sub.9 is independently hydrogen or C.sub.1 -C.sub.4 alkyl and the others are independently chosen from hydrogen, hydroxy, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and --COOR, wherein R.sub.7 is as defined above, and one of R.sub.5 and R.sub.6 is hydrogen and the other is hydrogen, C.sub.1 -C.sub.6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier and/or diluent.

'N-imidazolyl derivatives of bicyclic compounds and pharmaceutical

Alkoxy methyl pyrazine N-oxides having anti lypolytic, hypotriglyceridemic and hypocholesterolaemic properties and utility are disclosed.

Ethers of substituted hydroxymethlypyrazines

The compounds of the invention have the following general formula (I) ##STR1## wherein each of the groups R, R.sub.1 and R.sub.2, which may be the same or different, represents a hydrogen atom, a C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkyl group, and R.sub.3 represents a straight or branched chain, saturated or unsaturated, C.sub.1 -C.sub.8 aliphatic hydrocarbon group. The compounds are useful as antilipolytic agents.

Ethers of substituted hydroxymethylpyrazines

Compounds of the formula (I) ##STR1## wherein the symbol   represents a single or a double bond;

N-imidazolyl derivatives of bicyclic compounds

Platelet aggregation inhibiting compositions and methods of use containing compounds of the formula ##STR1## where Z completes a bond or is a ##STR2## group; one of R.sub.1 and R.sub.2 is hydroxy and the other is hydrogen or alkyl, or R.sub.1 and R.sub.2, taken together, form an oxo group; and the remaining substituents are as defined in the specification.

N-imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene and indan as

Compounds of the formula (I) ##STR1## wherein the symbol   represents a single or a double bond; Z completes a single bond or is a --CH.sub.2 -- group; each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different is

N-Imidazolyl derivatives containing naphthalene or indene nucleus

Compounds of the formula ##STR1## where Z completes a bond or is a ##STR2## group; one of R.sub.1 and R.sub.2 is hydroxy and the other is hydrogen or alkyl, or R.sub.1 and R.sub.2, taken together, form an oxo group;

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Milan, Italy

Antonio Pillan