University of Connecticut

Antonio P Costa

Diane J Burgess

The present disclosure provides a system for the internal and external modification of nanoparticles in a continuous process. The system includes (a) a first inlet, (b) a second inlet, (c) a first pump in fluid communication with the first inlet, (d) a second pump in fluid communication with the second inlet, (e) a first flow meter positioned between the first pump and the first mixer, (f) a second flow meter positioned between the second pump and the first mixer, and (g) a mixing chamber in fluid communication with the first flow meter and the second flow meter, and (h) a first heat exchanger in fluid communication with the mixing chamber.

Continuous processing system and methods for internal and external modifications to nanoparticles

The present disclosure provides systems and methods for the continuous production of liposomes. An example method includes (a) mixing a solution of lipid and organic solvent from one or more containers to create an organic solvent-lipid solution, (b) providing the organic solvent-lipid solution to a first inlet of an injection port at a first flow rate, wherein the first inlet is in fluid communication with a first conduit, (c) providing an aqueous solution to a second inlet of the injection port at a second flow rate, wherein the second inlet is influid communication with a second conduit, wherein the first conduit is positioned concentrically within the second conduit at an outlet of the injection port, and wherein the first conduit extends through the outlet of the injection port, and (d) mixing the organic lipid solution and the aqueous solution to create a plurality of liposomes.

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Farmington, CT, United States of America

Antonio P Costa