Universidade De Santiago De Compostela

Servizo Galego De Saude (sergas)

Universidade Da Coruña

Endotherm Gmbh

Antonio Mouriño Mosquera

Miguel A Maestro Saavedra

Borja Lopez Perez

Rita Sigueiro Ponte

Samuel Seoane Ruzo

Jose Esteban Castelao Fernandez

Pranjal Gogoi

Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.

Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives

The present invention relates to compounds of pharmaceutical interest. More particularly, it relates to compounds of formula (I), to processes for obtaining thereof, to the intermediates of their synthesis and processes for obtaining the latter. The compounds of formula (I) have a certain affinity with the vitamin D receptor, they are active in a similar order to 1,25&#x3b1;-dihydroxyvitamin D(1,25D), with the advantage of producing less or no hypercalcemia.

Vitamin D analogues of pharmaceutical interest

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Santiago de Compostela, Spain

Antonio Mouriño Mosquera