Other

Wisconsin Alumni Research Foundation

Nibon University

Antonio Mouriño

Hector Floyd Deluca

Lori A Plum

Margaret Clagett-Dame

Rafal R Sicinski

Sachiko Yamada

Katarzyna Sokolowska

Makoto Makishima

Hiroaki Tokiwa

Kazuki Maekawa

Takeru Kudo

Yusuke Watarai

The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof. 

Vitamin D receptor modulators with partial agonist activity

This invention discloses 6-methylvitamin Danalogs, and specifically 1&#x3b1;,25-dihydroxy-6-methylvitamin D, and pharmaceutical uses therefor. This compound exhibits vitamin D receptor binding activity and transcription activity as well as activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent, especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. This compound also exhibits low in vivo calcemic activity, but because it binds the receptor with the same affinity as the native hormone calcitriol, it may act as an antagonist to inhibit development of hypercalcemia.

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Growing community of inventors

Ames, Spain

Antonio Mouriño