Acs Dobfar S.p.a.

Antonio Manca

Maurizio Zenoni

Riccardo Monguzzi

Leonardo Marsili

Giovanni Fogliato

Mauro Freccero

Michele Bassanini

Bruno Sala

Preparation of new heterocyclic compounds characterized by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1&#x3b2;-methylcarbapenem production.

1,3 imidazolidine derivatives and their use in the production of carbapenem

Cefalotin is methoxylated in position 7&#x3b1;, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.

Process for preparing sodium cefoxitin

The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Alions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which practically tautomer-free cefotetan is obtained.

Process for obtaining cefotetan with high yield

Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.

Process for producing Cefepime and cephalosporin analogues

Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein:

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Milan, Italy

Antonio Manca