Intercept Pharmaceuticals, Inc.

Consiglio Nazionale Delle Ricerche

Università Degli Studi Di Perugia

Antonio Macchiarulo

Roberto Pellicciari

Antimo Gioiello

Françoise Perron-Sierra

Klaus Seedorf

Marsha Pellegrino

Fabiola Moretti

Francesca Mancini

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

TGR5 modulators and methods of use thereof

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

Growing community of inventors

Perugia, Italy

Antonio Macchiarulo