Smithkline Beecham Corporation

Antonio Kuok Keong Vong

Christopher Norbert Johnson

Mervyn Thompson

Geoffrey Stemp

Michael S Hadley

Robert William Ward

Gregor James MacDonald

Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents)

Tetraisoquinoline derivatives as modulators of dopamine D3 receptors

Compounds of formula (I) and pharmaceutically acceptable salts thereof, where G is a methylene or ethylene linkage; R is hydrogen, C alkylO&mdash;; R is hydrogen, halogen, CN, N , trifluoromethyldiazirinyl, CF , CF O&mdash;, CF S&mdash;, CF CO&mdash;, C alkyl, C cycloalkyl, C cycloalkyl-C alkyl-, C alkylO&mdash;, C alkylCO&mdash;, C cycloalkylCO&mdash;, C cycloalkyl-C -alkylCO&mdash;, phenyl, phenoxy, benzyloxy, benzoyl and substituted benzoyl, phenyl-C alkyl-, C alkylSO &mdash;, (C alkyl) NSO &mdash; or (C alkyl)NHSO &mdash;; R is hydrogen, halogen, CN, N , trifluoromethyldiazirinyl, C alkylO&mdash;, C alkylS&mdash;, C alkyl, C cycloalkyl, C cycloalkyl-C alkyl-, C alkenyl, C alkynyl, CF CO&mdash;, C alkylCO&mdash;, C cycloalkylCO&mdash;, C cycloalkyl-C alkylCO&mdash;, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C alkyl-, or &mdash;NR R where R is hydrogen or C alkyl; and R is hydrogen, C alkyl, &mdash;CHO, &mdash;CO C alkyl or &mdash;COC alkyl; R is hydrogen, C alkyl, C alkenyl, or C alkynyl, are useful in the prevention and treatment of anxiety, mania, depression disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, etc.

Substituted benzamide derivatives and pharmaceutical compositions containing them

Growing community of inventors

Sawbridgeworth, United Kingdom

Antonio Kuok Keong Vong