Gilead Connecticut, Inc.

Genentech, Inc.

Boehringer Ingelheim Pharmaceuticals, Inc.

Genetech, Inc.

Antonio J M Barbosa

Kevin S Currie

Scott A Mitchell

Peter A Blomgren

Jeffrey E Kropf

Jianjun Xu

Seung H Lee

Zhongdong Zhao

Daniel Fred Ortwine

Wendy B Young

Aaron C Schmitt

Pavel E Zhichkin

Xiaojing Wang

Honglu Zhang

Ravi Krishnamoorthy

Eugene R Hickey

Steven Richard Brunette

Jin Mi Kim

Matt Aaron Tschantz

Bryan Patrick McKibben

René Marc Lemieux

Hui Yu

Michael David Lawlor

William Martin Rennells

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. 

Pyridone and aza-pyridone compounds and methods of use

Compounds of Formula I that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described. 

Pyridazinones, method of making, and method of use thereof

Disclosed are novel compounds of formula (I): wherein X, Y, R, Rand Rare as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Pyrimidine derivatives useful as inhibitors of PKC-theta

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Middlebury, CT, United States of America

Antonio J M Barbosa