Aviva Biosciences Corporation

Antonio Guia

Lei Wu

Mingxian Huang

Jia Xu

Xiaobo Wang

George T Walker

David M Rothwarf

Julian Yuan

The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips.

High-density ion transport measurement biochip devices and methods

The present invention recognizes that the determination of an ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport functions or properties using microfabricated structures that can allow for automated detection of one or more ion transport functions or properties. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport functions or properties, particularly for screening purposes.

Biochips including ion transport detecting structures and methods of use

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San Diego, CA, United States of America

Antonio Guia