Other

Warner-lambert Company

The University of Oklahoma

Antonio Guglietta

Michael Francis Rafferty

Charles Price Taylor, Jr

Lionel Bueno

Laurent Diop

Maria Chovet

William Patrick Watson

Hilary J Little

Jiayuan Ren

Indu Parikh

Ronald V Nardi

Tanchum Amarant

W P Watson

GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.

Method for preventing and treating alcoholism

Method for preventing and treating pain

GABA analogs to prevent and treat gastrointestinal damage

The present invention comprises a method for treating inflammatory bowel disease (IBD) by administering to a mammal in need thereof a therapeutically effective amount of at least one histamine H.sub.3 -receptor agonist. It has been unexpectedly found that H.sub.3 -receptor agonists are effective at alleviating the effects of IBD and, therefore, are useful for treating IBD, including ulcerative colitis and Crohn's disease.

Treatment of inflammatory bowel disease using histamine H.sub.3

The invention in growth factor compositions includes: a novel compound which is a separate pure nicked or pure non-nicked species of epidermal growth factor EGF1-48 or its hEGF1-47 or hEGF1-49 congener compound, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition in dosage form comprising an effective amount of the novel compound and/or the known hEGF1-53; and use thereof for treating abnormal cell growth conditions including gastrointestinal/duodenal lesions; and methods of making the pure novel hEGF species. This unique therapeutic utility is enhanced by the unexpected and heretofore unappreciated structural stability and resistance of the pure species to enzymatic degradation.

Growth factor compositions, preparation and use

Growing community of inventors

Ann Arbor, MI, United States of America

Antonio Guglietta