St. Jude Children's Research Hospital

University of Tennessee Research Foundation

Antonio Ferreira

Jaeki Min

Brandon M Young

Nagakumar Bharatham

R Kiplin Guy

Richard Kriwacki

Michael Dyer

Donald Bashford

Yiqun Zhang

Lie Min

Kristin Finch

Grace Roy-Appa

Bob M Moore, Ii

Grace Royappa

Mathangi Krishnamurthy

The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Aryl-substituted imidazoles

1'-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having activity as either agonists or antagonists of the CB-1 and/or CB-2 receptors can be used for treating CB-1 or CB-2 mediated conditions.

Cannabinoid derivatives, methods of making, and use thereof

Growing community of inventors

Memphis, TN, United States of America

Antonio Ferreira