Medimmune Limited

University of Georgia Research Foundation Inc

Antonio Digiandomenico

Charles K Stover

Ralph Raymond Minter

Sandrine Guillard

Steven Rust

Mladen Tomich

Paul Warrener

Bret Sellman

Changshou Gao

Partha S Chowdhury

Nazzareno Dimasi

Reena Varkey

Ryan Fleming

Binyam Bezabeh

Vignesh Venkatraman

Melissa Marie Damschroder

Godfrey Rainey

Cuihua Gao

Li Peng

Geert-Jan Boons

Michael P McCarthy

Qun Wang

Brett R Sellman

Hasan Jafri

Xiang-Qing Yu

Brian Bishop

Kai-For Mo

Huiqing Li

Paul G Warrener

Ralph Minter

This disclosure relates to combination therapies comprising anti-Psl and PcrV binding molecules and related compositions, for use in prevention and treatment ofinfection.

Combination therapies using anti-pseudomonas PSL and PCRV binding molecules

This disclosure relates to polynucleotides encoding antibodies or antigen binding fragments thereof that bind toPcrV as well as vectors and host cells comprising the same.

Polynucleotides encoding antibodies or antigen binding fragments thereof that bind pseudomonas perv

A method for preventing or treating nosocomial diseases, e.g., diseases caused by, is provided. The method includes administering to a susceptible human subject a specified dose of a bispecific antibody that specifically bindsPsl and PcrV.

Method for preventing or treating nosocomial pneumonia

This disclosure relates to synthetic oligosaccharide subunits of theexosaccharide Psi and uses thereof, e.g., for epitope mapping of anti-Psl antibodies, for identification of anti-Psl antibodies, and for use as vaccines. In one aspect a synthetic oligosaccharide subunit of aPsl oligosaccharide is provided, comprising the trisaccharide of formula I.

Synthetic oligosaccharide subunits of the Psl exopolysaccharide of pseudomonas aeruginosa and uses thereof

This disclosure relates to an anti-Psl binding molecule and uses thereof, in particular in prevention and treatment ofinfection. Furthermore, the disclosure provides compositions and methods for preventing and treatinginfection.

Anti-Psl binding molecules and uses thereof

The disclosure relates to an anti-PSL binding molecule and uses thereof, in particular, in prevention and treatment ofinfection. Furthermore, the disclosure provides compositions and methods for preventing and treatinginfection.

Anti-pseudomonas Psl binding molecules and uses thereof

The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins.

Multispecific and multivalent binding proteins and uses thereof

Growing community of inventors

Gaithersburg, MD, United States of America

Antonio Digiandomenico