Universitá Degli Studi Di Genova

Biosearch Italia S.p.a.

University of Minnesota

Gruppo Lepetit

University of Genoa

Nutravis S.r.l.

Centro Biotecnologie Avanzate

Antonio De Flora

Umberto Benatti

Elena Zocchi

Mirko Magnone

Marco Giovine

Giovanna Basile

Santina Bruzzone

Luisa Franco

Lucrezia Guida

Timothy F Walseth

Robert A Aarhus

Gianluca Damonte

Hon Cheung Lee

Enrico Millo

Annalisa Salis

Marina Podesta

Giovanni Del Re

Long Wong

Ernesto Fattorusso

Orazio Taglialatela-Scafati

Sonia Scarfi′

Iliana Moreschi

Alessia Grozio

Sonia Scarfi'

The invention relates to the use of a very low dosage form of abscisic acid (ABA) or an in vivo hydrolysable conjugate thereof, preferably ABA-glucosyl ester (ABA-GE), for nutracentic/therapeutic use for controlling and/or preventing hyperglycaemia and weight gain in response to sugar intake with a reduction in insulin secret and an increase in muscle performance.

Treatment for improving the use of dietary sugar for energy purposes

The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD. 

Adenyl dinucleotides with antitumour activity and a method of preparing thereof

The invention relates to a novel use of fluridone&#x2014;compound known per se and used as an aquatic erbicide&#x2014;in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an inhibitor.

Fluridone as an anti-inflammatory agent

Cyclic-ADP-ribose analogs

5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthing-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.

Dinucleoside-5', 5'-pyrophosphates administered to treat HIV

Dinucleoside-5',5'-pyrophosphates

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Genoa, Italy

Antonio De Flora