Applied Research Systems Ars Holding N.v.

Clive Froud

Jose A. Gil

Tomas V. Garcia

Juan F. Martin

Antonio D. Ortega

Antonio D Ortega

Juan F Martin

Tomas V Garcia

Jose A Gil

The cloning and characterization of a newly isolated gene, referred to as saf (secondary metabolism activation factor) is disclosed. This gene encodes a new amino acid polypeptide, referred to as the SAF polypeptide, which directly or indirectly modulates the expression of extracellular enzymes in Steptomyces. DNA units or fragments which encode the SAF polypeptide are also disclosed, as are vectors containing said DNA, host organisms transformed with such vectors, and processes for preparing extracellular enzymes or heterologous polypeptides by culturing such host organisms.

SAF polypeptide gene coding therefor, and SAF promoter

The cloning and characterization of a newly isolated gene, referred to as saf (secondary metabolism activation factor) is disclosed. This gene encodes a new amino acid polypeptide, referred to as the SAF polypeptide, which directly or indirectly modulates the expression of extracellular enzymes in Streptomyces. DNA units or fragments which encode the SAF polypeptides are also disclosed, as are vectors containing said DNA, host organisms transformed with such vectors, and processes for preparing extracellular enzymes or heterologous polypeptides by culturing such host organisms.

SAF polypeptide, gene coding therefor, SAF promoter and expression

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Benacazon, Spain

Antonio D Ortega