Lay Line Genomics S.p.a.

Medical Research Council

Scuola Internazionale Superiore Di Studi Avanzati

Abbott Research B.v.

S.i.s.s.a.- Scuola Internazionale Superiore Di Studi Avanzati

Antonio Cattaneo

Flaminia Pavone

Sara Marinelli

Gabriele Ugolini

Michela Visintin

Doriano Lamba

Sonia Covaceuszach

Terenos Rabbits

Tse Wai-Choi Eric

Ugolini Gabriele

According to the invention there is provided use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA combined with at least one opioid analgesic for the preparation of a medicament for treating and/or preventing pain.

Method for the potentiation of opioid analgesics effects on pain

Use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA, in particular capable of blocking the biological activity of TrkA, for the preparation of a medicament for treating and/or preventing chronic pain.

Analgesic treatment with prolonged effect

A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows the selection of immunoglobulins which are capable of functioning in an intracellular environment.

Selection of intracellular immunoglobulins

Growing community of inventors

Rome, Italy

Antonio Cattaneo