Blasinachim S.p.a.

Antonio Bonaldi

Egidio Molinari

Process for preparing chenodeoxycholic substantially free from impurities and from solvents; crude chenodeoxycholic acid is subjected to crystallization from a solvent selected in the group consisting of mono- and polyhalogenated aliphatic hydrocarbons containing from 1 to 5 carbon atoms and that, if desired, the thus obtained product is dissolved in a water-miscible organic acid having low molecular weight and the thus obtained solution is poured into water, the precipitate is poured into water, the precipitate is collected by filtration, washed with water and dried.

Process for the purification of chenodeoxycholic acid

The humid amorphous form of chenodeoxycholic acid undergoes a physical treatment at room temperature comprising causing a collision of the particles of the amorphous product in bulk by means of shaking or stirring to prepare the solvent-free crystalline form of chenodeoxycholic acid which melts at 168.degree.-170.degree. C.

Process for preparing a crystalline polymorphous type of

A mixture of ursodeoxycholic acid and of chenodeoxycholic acid as well as of their salts and esters is reacted with a silylating agent in a suitable anhydrous organic solvent; the corresponding silyl-derivatives thus obtained are separated by crystallization and pure ursodeoxycholic acid is recovered from the corresponding silyl-derivatives in the usual manner.

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Schilpario, Italy

Antonio Bonaldi