Eniricerche S.p.a.

Enichem S.p.a

Polifarma S.p.a.

Eni-ente Nazionale Idrocarburi

Antonino Virdia

Antonio S Verdini

Alessandro Sisto

Vincenzo Politi

Giovanna De Luca

Giovanni Di Stazio

Tripeptides having hypotensive activity, defined by the following general formula:

Tripeptide compounds having hypotensive activity

Retro-inverted peptides, analogues of Bradykinin Potentiator Pentapeptide (BPP.sub.5a), definable by the general formula (I) ##STR1## useful as antihypertensives and diagnostics.

Retro-inverted peptides analogues of Bradykinin Potentiator BPP.sub.5a

Peptido-mimetic compounds of hypotensive action definable by the general formula: ##STR1## in which: X represents the pyroglutamic acid residue or a ##STR2## residue where R.sub.2 represents a hydrogen atom, an alkyloxycarbonyl, an arylalkyloxycarbonyl or an acyl group with from 1 to 7 carbon atoms in the linear chain,

Peptido-mimetic substances with hypotensive action

New partially retro-inverso peptides of the following general formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent, each independently, the side chain of the aminoacid residues present in the naturally occuring peptides, X is --S--Ph or --O--CH.sub.2 --Ph and Z is a hydroxy, alkoxy or amino group, are described as well as a suitable method for their preparation. The new compounds are useful as antihypertensive agents.

Retro-inverso analogs of the bradykinin potentiating peptide BPP.sub.5a

This invention relates to new retro-inverso peptides and peptide derivatives in the form of analogues of the bradykinin potentiating peptide (BPP.sub.5a), which are pharmacologically active, have long in vivo life and are useful as antihypertensives and diagnostic drugs, their general formula (I) being ##STR1##

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Antonino Virdia