Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Betaglue Technologies S.p.a

Istituto Nazionale Di Fisica Nucleare

Antonino Amato

Giovanni Paganelli

Menotti Calvani

Giada Petringa

Giuseppe Antonio Pablo Cirrone

Francesco Romano

Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.

Compositions, devices and kits for selective internal radiation therapy

Acetyl L-carnitine, or of one of its pharmaceutically acceptable salts, is useful for the prevention of painful peripheral neuropathy in patients suffering from type 2 diabetes, in which symptoms are pain, paraesthesia or hyperaesthesia. The acetyl L-carnitine is administered orally at a dose of at least 3 grams/day.

Acetyl L-carnitine for the preparation of a medicament for the prevention of painful peripheral neuropathy in patients with type 2 diabetes

Acetyl L-carnitine for prevention of painful peripheral neuropathy in patients with type 2 diabetes

The present invention discloses a method for treating a subject suffering from intermittent claudication (IC) wherein said subject takes an effective dose of propionyl L-carnitine or a pharmaceutically acceptable salt thereof and also engaging in a concomitant physical training program. The method is particular effective for patients with intermittent claudication at class II of the Leriche-Fontaine's classification. The method provides a relief from peripheral arterial disease symptoms, as shown by claudication-limited exercise tolerance, while also improving quality of life.

Method for treating intermittent claudication comprising the administration of propionyl L-carnitine and a concomitant physical training

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Rome, Italy

Antonino Amato