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Institute of Organic Chemistry and Biochemistry of the Academy of

Rega Stichting, V.z.w.

Institute of Organic Chemistry

Biochemistry of the Academy of Sciences of the Czech Republic

K.u. Leuven Research & Development

Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic

Ustav Organicke Chemie a Biochemie Akademie Ved Ceske Republiky

Antonin Holy

Johan Neyts

Erik D De Clercq

Erik De Clercq

Erik D A De Clercq

Jan M R Balzarini

Jan Marie Rene Balzarini

Hana Dvorakova

Lieve Naesens

Erik Desire Alice De Clercq

Robert Snoeck

Dana Hockova

Graciela Andrei

Marcela Krecmerová

Alois Piskala

Novel compounds are provided having formula (I) where R, R, R, R, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

Phosphonate substituted pyrimidine compounds and methods for therapy

Antiviral compounds and methods for synthesis and therapy

Antiretroviral enantiomeric nucleotide analogs

Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivirals. Of particular note are compounds otherwise not known to possess anti-DNA viral activity that become potent inhibitors of DNA viruses upon substitution of the N-6 site, thereby providing a novel and unexpected and surprising use for such compounds.

N.sup.6 - substituted nucleotide analagues and their use

Growing community of inventors

Horni Pocernice, Czechia

Antonin Holy