Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu

Spojene Podniky Pro Zdravotnickou Vyrobu

Antonin Dlabac

Miroslav Protiva

Jirina Metysova

Karel Sindelar

Jiri Jilek

Josef Pomykacek

Jiri Krepelka

Evzen Kasafirek

Miroslav Rajsner

Ivan Krejci

Milan Pesak

Arnost Pospisil

Martin Valchar

Jiri Vanzura

Antonin Sturc

Irena Cervena

Jirina Cizkova

Vaclav Bartl

Leon Langsadl

Vaclav Plaisner

Frantisek Miksik

Jirj Kohout

Libuse Korbova

A cell-protective composition for preventing or treating of a peptic ulcer due to topical endogenous lesion of gastric or duodenal mucous membrane comprises as a physiologically active component the cyclo-(1-alanyl-amino-1-cyclopentanecarbonyl)cyclodipeptide. The subject composition is designated for administration by oral or parenteral route. It is substantially non-toxic and well tolerated, and acts beneficially, even at low dosage level.

Cell-protective composition for preventing or treating of peptic ulcer

N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepins are disclosed of the general formula I, ##STR1## in which R represents an aminocarbonyl, amino-oximinomethyl, 1,3-dioxolan-2-yl or 1,3-dioxan-2-yl, group and their addition salts with convenient organic and inorganic acids. These compounds are highly potent antidopaminergic, non-cataleptic neuroleptics of use in the treatment of schizophrenia. According to recent pharmacological assay results, the subject compounds are expected to be substantially free of the usual undesired extrapyramidal side effects. They can be obtained by common preparative methods from the respective starting compounds of formula III, IV or V, or also by appropriate interconversion reactions of other compounds of formula I. If required, the resulting bases are neutralized with suitable acids, preferably methanesulfonic, maleic or hydrochloric acid, to yield the corresponding addition salts that can be used in formulating proper dosage forms for pharmacological evaluation and therapeutical application.

N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo (B,F)

A technique is described for the preparation of a wide variety of basic derivatives of linearly condensed tricyclic systems formed by two external benzene nuclei and a 7-membered central ring having 2 chalcogen atoms as hetero atoms. Derivatives of 11H-dibenzo(b,e)-1,4-dioxepin are obtained when the chalcogens are both oxygen atoms; derivatives of 11H-dibenzo(b,f)-1,4-dithiepin are obtained when the chalcogens are both sulfur atoms; derivatives of 6H-dibenz(b,e)-1,4-oxathiepin and 11H-dibenz(b,f)-1,4-oxathiepin are obtained with combinations of sulfur and oxygen atoms as chalcogens.

Tricyclic compounds

Techniques for the preparation of 3-fluoro-10-piperazino-8-substituted 10,11-dihydrodibenzo-(b,f) thiepins and their addition salts with organic and inorganic acids are disclosed. The described compositions evidence psychotropic activity and low toxicity and are characterized as neuroliptics with a high degree of cataleptic, anti-apomorphine and central depressant action.

3 Fluoro-10-piperazino-8-substituted 10,11-dihydrodibenzo-(bf) thiepins

Growing community of inventors

Prague, Czechia

Antonin Dlabac