Forest Laboratories Holdings Limited

Merz Pharma Gmbh & Co Kgaa

Antonia Periclou

Mahendra G Dedhiya

Niranjan Rao

Wattanaporn Abramowitz

Shashank Mahashabde

Suneel K Rastogi

Bernhard Hauptmeier

Erhard Seiller

Yan Yang

Rajiv Janjikhel

Wattanporn Abramowitz

The present invention provides pharmaceutical compositions given once daily containing at least one therapeutically active ingredient selected from the group consisting of memantine and a pharmaceutically acceptable salt of memantine, and a pharmaceutically acceptable polymeric matrix carrier. The dosage forms of the invention sustain the release of the therapeutically active agent from about 4 to about 24 hours when said dosage form is exposed to aqueous solutions. following entry of said form into a use environment, wherein said dosage form has a dissolution rate of more than about 80% after passage of about 6 hours to about 12 hours following said entry into said use environment.

Modified release formulations of memantine oral dosage forms

The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average Twithin the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of T.

Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane

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Jersey City, NJ, United States of America

Antonia Periclou