Indena S.p.a.

Antonella Riva

Paolo Morazzoni

Ezio Bombardelli

Gabriele Fontana

Massimo Ronchi

Roberto Seghizzi

Nicola Fuzzati

Andrea Giori

Cesare Ponzone

Vincenzo Di Marzo

Giovanni Appendino

Fabrizio Corti

Marcello Duranti

Carla Manzotti

Federico Peterlongo

Giacomo Mombelli

Davide Berlanda

Elisabetta Frattini

Renato Iori

Sabrina Arpini

Alessandro Consonni

Disclosed are compositions including berberine combined with pea proteins and one or more surfactants. Also disclosed are processes for the preparation of the compositions, and the formulations and uses thereof.

Compositions comprising berberine

Disclosed are powder solid dispersions including quercetin, phospholipids and a very to freely water soluble carrier. Also disclosed are a process for the preparation of the powder solid dispersions and pharmaceutical, nutraceutical and cosmetic compositions including the solid dispersions.

Powder solid dispersions comprising quercetin, process for their preparation and formulations thereof

Disclosed is a compound having the formula a) or b); a: R=CH; b: R=CHCH, and its use in the prevention and/or treatment of Alzheimer's disease. 

Hyperforin derivatives and their use in Alzheimer's disease

The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.

Formulations with sanguinarine, chelerythrine or chelidonine for the treatment of warts, verrucas and psoriatic plaques

The invention concerns the use of glucomoringin and of its des-thio-glucoside having the following formulae (I, II): for the preparation of a medicament for the treatment of myeloma. 

Use of isothiocyanate derivatives as anti-myeloma agents

A truncated form of &#x3b1;' chain (e&#x3b1;&#x2032;), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha&#x2032; subunit. The e&#x3b1;&#x2032; polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.

Cloning, yeast expression, purification and biological activity of the extension region of the soybean 7S globulin alfa' subunit involved in HEP G2 cell cholesterol homeostasis

The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.

Compositions for the treatment and prevention of infections of the oral cavity

The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.

Antitumoral agents with a benzophenanthridine structure and formulations containing them

The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.

Hyperforin derivatives, the use thereof and formulations containing them

Pharmaceutical compositions containing: extracts ofin the weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; and optionally arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions are useful in the treatment of male and female sexual dysfunctions. A method of treatment using the pharmaceutical compositions is also described.

Formulations useful in the treatment of male and female impotence

The compounds of the general formula (I) in which X is represents two hydrogen atoms, a &#x3c0;-bond, oxygen or methylene: R2 is a C-Caryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I. 

TRPV1 agonists, formulations containing them and uses thereof

Disclosed are pharmaceutical compositions containing: extracts ofandin the weight ratio of 1.5&#x2013;3.5:1&#x2013;2:0.1&#x2013;0.4 respectively;extract, and optionally arginine or a physiologically equivalent esters salts or precursor thereof. The compositions according to the invention are useful in the treatment of male and female sexual dysfunctions.

Growing community of inventors

Milan, Italy

Antonella Riva