Sanofi Pasteur Inc.

Anton Novak

Michel Henri Klein

Heather A Boux

Diane M Gajewczyk

A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxifiedholotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxifiedholotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.

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Toronto, Canada

Anton Novak