Genzyme Corporation

Integrated Genetics, Inc.

Anton K Beck

Nancy Hsiung

Edward G Bernstine

Vermuri B Reddy

Edward G Berstine

Vemuri B Reddy

Nicholas C Masiello

James R Zabrecky

Vermuni B Reddy

Raymond M Withy

Biologically active heteropolymeric protein composed of a plurality of subunits, both subunits being synthesized in a single cell having an expression vector comprising heterologous DNA encoding the subunits. Preferably the protein is similar to the human or ungulate fertility hormones, LH and FSH.

Cells, vectors and methods for producing biologically active TSH

Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.

Nucleic acids encoding and recombinant production of the .beta. subunit

Recombinant heterodimeric human fertility hormones, and methods, cells,

The correct sequence is disclosed for the beta subunit of human follicle stimulating hormone which, when present in a recombinant heterodimeric human fertility hormone allows the production of biologically active hormone. DNA coding for such beta subunit of human FSH may thus be prepared as well as expression vectors containing such DNA and cells transfected therewith.

DNA encoding the beta subunit of human follide stimulating hormone and

Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.

Follicle stimulating hormone

A rodent epithelioid cell transformed with a recombinant DNA vector including a DNA sequence encoding human erythropoietin, the transformed cell being capable of producing N-linked and O-linked glycosylated human erythropoietin.

Cell encoding recombinant human erythropoietin

Biologically active heteropolymeric protein composed of a plurality of subunits, each subunit being synthesized by a cell having an expression vector heterologous DNA encoding the subunit.

Heteropolymeric protein

A cDNA sequence encoding porcine beta FSH.

Growing community of inventors

Chestnut Hill, MA, United States of America

Anton K Beck