Roche Diagnostics Operations, Inc.

Bausch-lomb Incorporated

Technolas Perfect Vision Gmbh

Anton Hilger

Gerhard Youssefi

Daniel Intelmann

Julia Hoff

Andrea Geistanger

Shirin Shahriari

Nadja Arens

Michael L Kliewer

A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function ffor a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fdescribes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fis a parametrized function f(concentration), with p=(p,p, . . . p) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)},{circumflex over (p)}, . . . {circumflex over (p)}) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.

Method for calibrating at least one mass spectrometry device

A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sis acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.

Method for calibrating at least one analytic device with multiple repeated hardware components

A method and an apparatus for extrapolating diagnostic data relating to one pupil diameter to another pupil diameter. Embodiments according to the invention are more particularly directed to extrapolating wavefront aberration data, for example, in the form of Zernike polynomial data, obtained from a smaller pupil diameter, d, to a larger pupil diameter, d. Data relating to the first pupil diameter dmay be obtained in a diagnostic procedure. In the extrapolation, a conversion matrix M is utilized. The conversion matrix M can be generated from a static matrix and a dynamic matrix, the latter taking the pupil diameter dinto consideration. Data relating the first pupil diameter dand wavefront aberration data can be ordered via a permutation matrix P. If necessary, Extrapolated data can be re-ordered via a transposed permutation matrix P. The extrapolated data relating to the pupil diameter dcan be processed to obtain an ablation profile, a shot file, or other data for a refractive vision correction treatment.

Method and apparatus for extrapolating diagnostic data

The invention relates to an apparatus and a method for determining the applicability of a treatment pattern for manipulation of a cornea of an eye using a laser. The concept of the present invention is based on the determination of an actual volumetric profile based on a set of input data and a theoretical volumetric profile which is created independently based on only the basic optical parameters. On the basis of a comparison of the determined volumetric profiles it is determined whether the actual volumetric profile is within predetermined tolerances.

Treatment pattern monitor

A method and apparatus for remotely verifying the calibration status of a diagnostic instrument, for example, following remote installation of a software upgrade on the instrument. In one example, a method of verifying the calibration status of the instrument, includes retrieving stored raw calibration test data generated during a previously-performed calibration of the instrument, processing the raw calibration test data to generate a diagnostic reading, comparing the diagnostic reading to a known nominal reading, and based on the comparison, generating an output indicative of the calibration status of the instrument. In one example, the method is performed without contemporaneously measuring a calibration object with the instrument and therefore, without activating the measurement head or measurement optics of the instrument.

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Munich, Germany

Anton Hilger